ABSTRACT
Erythrocyte structure was studied in rat after uranyl nitrate (UN:5 mg/kg) intoxication. The study of pathogenic progression of UN induced renal failure (ARF) was confined to the early initiation phase (2 hr), late initiation phase (8 hr) and the maintenance phase (24 hr). Erythrocyte structure has been found to be greatly influenced. The UN induced hemolytic syndrome/hypoxia was accompanied by a marked anisocytosis and poikilocytosis during different phases of ARF, which is characteristic of UN poisoning. Subsequent alterations in erythrocyte structure followed by UN administration or during the pathogenic progression of ARF has clinical and diagnostic importance as the alterations were much distinct prior to the clinical manifestation of ARF even at light microscopic level.
Subject(s)
Animals , Blood Cell Count , Blood Urea Nitrogen , Creatinine/blood , Erythrocytes/drug effects , Hemoglobins/analysis , Acute Kidney Injury/chemically induced , Male , Rats , Uranyl Nitrate/toxicityABSTRACT
The alterations in the serum lipolytic activity of mice were studied under Uranyl nitrate (UN) intoxication. The lipemia produced as a result of UN intoxication was probed studying the alterations in the serum triacyl-glycerol-hydrolase (EC 3.1.1.3) activity. After an intraperitoneal injection of UN (10 mg/kg and 25 mg/kg), triacyl-glycerol-hydrolase (TAGH) activity was considerably enhanced. In the initiation phase the elevation in the activity was observed to be higher than the elevation in the maintenance phase of acute UN toxicity. The possible reasons for the elevation in the TAGH activity and its role under such intoxication is discussed.